2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38700The mortality and morbidity of liver cancer (hepatocellular carcinoma) in Taiwan are very high. Liver cancer in Taiwan is very complicated because it is strongly associated with hepatitis B, C and cirrhosis. Beside CT scan and angiography, the items of blood examination for clinical liver cancer diagnosis include AST、ALT、α-Feto Protein、bilirubin、 albumin、prothrombin time, and finally patients are classified into different stage according to TNM (tumor-node-metastasis) system defined by American Joint Committee on Cancer. However, these clinical analyses could not provide any information regarding the oxidation, inflammation, fibrosis, angiogenesis and energy metabolism, which are important factors contributed to the deterioration of liver cancer. In order to further understand the impact of these above biochemical changes on the pathological development of liver cancer, this project is designed to examine and compare the status of oxidation, inflammation, fibrosis, angiogenesis and energy metabolism for liver cancer patients at different TNM stage. This is a three-year project, and will collect at least 480 liver cancer patients from central area of Taiwan. Blood obtained from these patients will be used for many analyses. The purposes of this project are: 1) understanding the difference of oxidation, inflammation, fibrosis, angiogenesis and energy metabolism among patients at four TNM stages; 2) examine the impact of hepatitis B, hepatitis C or cirrhosis upon these biochemical changes in patients with liver cancer; 3) figuring out the correlation among these biochemical changes in liver cancer patients, and establishing the possible biomarkers for evaluating accurate liver function and predicting survival time. The results of this study will provide important findings to elucidate the roles of oxidation, inflammation, fibrosis, angiogenesis and energy metabolism in the progression of liver cancer, and explain the interrelationship between these variables, which will be useful for further clinical application and also enhance TNM clinical value. The proper biomarkers could be used as reference for evaluating the possible outcome of operation, chemo-therapy, and for selecting medicine and/or nutrients supplement, and also for predicting survival time.在台灣， 肝癌患者不但罹患人數多， 死亡率也很高。而且肝癌是與Ｂ 型肝炎、Ｃ 型肝炎或肝硬化高相關。國內臨床對肝癌病患的檢測包含血液 生化分析(肝功能、甲型胎兒蛋白、膽紅素、白蛋白及凝血.原時間)、腹部 超音波掃瞄、電腦斷層檢查與血管攝影等。然後依美國癌症學會所製訂之 TNM(tumor-node-metastasis)疾病分期系統將病患分類成stage I、II、III、IV 等期 別。雖然這些分析及TNM 分期有助於瞭解肝癌患者的病情及嚴重程度， 但 是對於患者的氧化狀態、發炎狀態、纖維化程度或癌化速度(如血管新生作 用)等卻無法提供重要訊息。然而肝癌患者的發炎、氧化、纖維化或癌化的 變化卻都能嚴重影響患者的病情進展、手術的成功機率、化療效果的預估、 乃至活存的時間。因此，若能分析及比較不同TNM 期別之肝癌患者的發炎、 氧化、纖維化、癌化或能量代謝的變化， 則可以進一步瞭解不同期別間這 些病理特徵的差異及彼此間的相關。相信這些訊息更有助於臨床醫師掌控 患者的病情， 這對於選擇治療模式及是否需要補充特定營養素也提供了參 考的依據。本研究擬在三年內收集至少480 位肝癌病患[TNM 四期， 三種肝 炎條件(B 肝、C 肝、無)， 二種硬化條件(有、無)的肝癌病患， 共24 組， 每 組20 人]。在初次診斷時即採血， 以血液進行各項分析。 本研究計畫的目的有三: 1)瞭解不同TNM 階段之肝癌患者，其氧化、發 炎、纖維化、能量代謝程度之差異； 2)探討B、C 型肝炎或肝硬化對肝癌患 者之氧化、發炎、纖維化及能量代謝的影響；3)分析肝癌患者之氧化、發炎 及纖維化等因子彼此間的相關， 嘗試找尋合適的biomarkers 可準確的評估肝 臟之實際功能狀態。本研究將以三年時間來進行， 研究工作將可以具體總 結氧化、發炎及纖維化在肝癌病理變化中扮演的角色； 瞭解B、C 型肝炎或 肝硬化對肝癌發展的影響； 以及確認可用以評估病情、手術及活存的 biomarkers。Project