蔡女滿古勤Nu-Man TsaiQin KU吳鎮峰Chan-Fong Ng醫學檢驗暨生物技術學系2026-10-159999-12-3120202020-06-24https://handle.ncl.edu.tw/11296/byufw7https://scholars.csmu.edu.tw/handle/123456789/22154肝癌是全球各地常見的惡性腫瘤之一，目前普遍認為肝癌的發生是由於部份肝臟細胞的無限增生及轉移，最終妨礙人體正常的生理功能而致死的疾病。近年隨着精準醫學的發展，對中藥的各種有效成份和相關藥物的作用機制的研究越來越深入，尋找天然的中藥成份作為緩解和抑制癌腫瘤的發展漸漸成為腫瘤治療的研究熱點。經綜合分析得出的結論，癌腫瘤細胞的增殖可與相關細胞的凋亡途徑失活或阻滯、富血管供養和端粒酶激活等有關。本文主要回顧中藥治療肝癌的幾個治療機制：誘導癌細胞凋亡、抑制血管新生、逆轉腫瘤細胞的耐藥性、抑制端粒酶的活性、殺死癌細胞、輔助治療、延緩病情發展和轉移等方面的資料進行整理，綜述近年中藥抗肝癌的作用機制的研究進展，為科學研究中藥抗肝癌之理論提供依據，期望能夠對中藥治療肝癌的發展領域的科學研究作出小小的貢獻。Liver cancer is one of the common malignant tumors around the world. It is generally recognized that the occurrence of liver cancer is due to the cell proliferation unlimited and out of control, and metastasis of some liver cells. Finally, the normal physiological functions of the human body are lost. With the development of precision medicine in a decade, the research on the various active constituent of traditional Chinese medicine and its mechanism of action is getting deeper and deeper. The search for traditional Chinese medicine ingredients as a relief and suppression of cancer development has gradually become a research hotspot in cancer treatment.According to the comprehensive analysis of the tumor, the proliferation of cancer cells can be related to the inactivation or blockage of metabolic pathways of related cells, vascular rich feeding, and telomerase activation. This article mainly reviews several treatment mechanisms of traditional Chinese medicine for liver cancer: inducing tumor apoptosis, inhibiting angiogenesis, inhibiting multidrug resistance, inhibiting telomerase activity, killing cancer cells, adjuvant therapy, delaying the development and metastasis of the disease. This review summarizes the research progress of the mechanism of action of traditional Chinese medicine against liver cancer in recent years and provides a basis for scientific research on the theory of traditional Chinese medicine against liver cancer.原發性肝癌中藥細胞凋亡抑制血管增生多藥耐藥性primary liver cancertraditional Chinese medicineapoptosisinhibiting angiogenesismultidrug resistancethesis