SHUN-FA YANGCHUN-WEN CHENGPEI-NI CHENCHIA-LIANG LINYI-HSIEN HSIEH2026-10-162026-10-162016-09-01Pure ID: 15130705Pure UUID: dc8aba6c-2219-4eb5-a4c4-75fb940a55c810.1007/s11060-016-2168-zhttps://www.scopus.com/pages/publications/84976319607https://scholars.csmu.edu.tw/handle/123456789/23351Pentraxin 3 (PTX3) is an inflammatory molecule that is involved in immune responses, inflammation, and cancer. Recent evidence suggests that PTX3 plays a critical role in tumor progression; however, its impact on the biological function of gliomas remains unknown. In the present study, immunohistochemical staining showed that patients with high-grade gliomas exhibited increased expression levels of PTX3 compared to those with low-grade gliomas (P < 0.001). Furthermore, knockdown of PTX3 in GBM8401 cells inhibits proliferation, increases p21 protein levels, and decreases cyclin D1 protein levels, resulting in cell cycle arrest at the G0/G1 phase. In addition, knockdown of PTX3 significantly decreases GBM8401 cell migration and invasion through the downregulation of matrix metalloproteinase-1 and -2 (MMP-1 and MMP-2) expression. In a GBM8401 xenograft animal model, PTX3 knockdown decreases tumor growth in vivo. In conclusion, PTX3 plays an important role in glioma cell proliferation and invasion, and may thus serve as a novel potential therapeutic target in the treatment of gliomas.9enjournal article