2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38808Previous studies reported that dentists had high prevalence of occupational health problems and were exposed to bioaerosols contaminated with viruses or bacteria, mercury, and methacrylates. These exposures were found to be associated with some disease/symptoms among dentists. It is necessary to conduct a long-term follow-up of this occupational group for incidence of diseases and changes in exposures and to delineate the exposures-disease incidence relationship. Furthermore, the occupational exposures, especially bioaerosols, and health status of dentists in Taiwan are not well understood and merit further investigation. The specific aims of this study are: (1) to implement a national survey for the health problems and occupational exposures among dentists; (2) to conduct a cohort study to follow up and assess the effects of occupational exposures on incidence of cancer, mortality, and other major health outcomes among dentists; (3) to monitor bacterial aerosols in dental clinics and workplace and to assess dentists’ and control subjects’ exposures to bacterial aerosols; (4) to investigate the association between bioaerosol exposure and Helicobater pylori infection among dentists and controls. This three-year epidemiological study has four main parts. The first part consists of the establishment of a cohort of dentists and the follow-up of the participants for morbidity/mortality, using both an internal and an external control groups. All 10700 licensed dentists will be invited to participate in the study by a mailed questionnaire and an invitation letter. The second part is a nationwide question survey of dentists for occupational exposures and job-related health problems. It is conducted along with the first-part study. The third part comprises a cross-sectional study of occupational bioaerosol exposure and health status between 120 dentists and 120 controls (researchers/teachers at universities) in Taichung city. Bioaerosol samples will be collected at dental clinics (dentists) and offices (controls) and analyzed for bacteria counts. Saliva samples collected from study subjects will be analyzed for Helicobater pylori infection by ELISA. The fourth part study is the first yearly follow-up of the cohort participants (estimated sample size: 3000-4000). Data analysis consists of descriptive statistics, bivariate analysis, and multiple logistic and linear regression analysis using SAS software. Cox proportional hazard model and multivariable logistic regression will be applied to assess the association between incident health outcomes and exposure for the cohort study. Results from the proposed study will help clarify the association between occupational exposures and health among dentists.研究指出牙醫師有高的職業相關健康問題，牙醫師在工作場所暴露於被細菌或病毒所污染的生物氣膠、汞及丙烯酸甲酯(methacrylate)，這些物質對牙醫師的健康可能有不良影響，然台灣牙醫師的職業暴露與健康狀況尚未被充分了解，本研究的主要目的為：(1)進行全國性調查，瞭解牙醫師的疾病盛行率與職業暴露；(2)建立全國牙醫師的研究世代，追蹤調查其疾病的發生; (3)偵測與分析牙醫師和對照組工作場所的生物氣膠，並評估生物氣膠暴露與Helicobater pylori感染的關係。此三年研究有四部份，首先是建立一個全國牙醫師的研究世代，郵寄問卷和邀請函給10700位牙醫師，並追蹤有意願參加者各疾病的發生。第二部份問為全國性調查，與第一部份同時進行，對象為第一部份調查中願意具名以及不願意具名參加者。第三部份針對台中市120名牙醫師和120對照者(教師/研究者)進行調查，以問卷收集健康與工作史資料，在工作場所採集生物氣膠樣本以及收集參加者的唾液樣本，分析其細菌種類與Helicobater pylori感染。第四部份是參加世代研究者(估計約3000-4000人)的第一次追蹤調查，以問卷收集疾病的發生情形。本研究將運用SAS軟體作資料分析，包括敘述性統計、雙因子分析、logistic regression，multiple regression、Cox proportional hazard model等。研究結果將幫助了解牙醫師的職業暴露與健康之關係。牙醫師職業暴露丙烯酸甲酯生物氣膠汞dentistoccupational exposuremethacrylatebioaerosolsmercuryProject