CHIN-TE HUANG2026-10-162026-10-162015-03-01Pure ID: 15164031Pure UUID: d2af3b1c-d923-49b6-a033-2d8d21026b0210.1016/j.dsi.2014.10.001https://www.scopus.com/pages/publications/84921438807https://scholars.csmu.edu.tw/handle/123456789/29007Background/Objectives Recently, fibrotic diseases such as hypertrophic scar, keloid, and scleroderma have been treated with UV-A1 radiation with encouraging results. However, conventional UV light sources are bulky and expensive. In this study, we aimed to verify the effectiveness of a portable UV-A1 radiation device in treating hypertrophic scars. Materials and methods A light-emitting diode array that emitted 365 ± 5 nm (UV-A1) was used to irradiate fibroblasts and hypertrophic scar in a rabbit model. Results In cell cultures, UV-A1 light exposure inhibited post-wound cell migration and reduced the total amount of soluble collagen production in fibroblasts. Type I collagenase production and its activity increased after treatment. On the rabbit ear, UV-A1 light irradiation reduced the thickness of hypertrophic scars, confirming the antifibrotic effect in vivo. Conclusion These results support the potential of a portable UV-A1 light device in treating hypertrophic scar.5enjournal article