吳得進Der-Jinn Wu林正盛Cheng-sheng Lin醫學研究所2026-10-282004-08-292004https://handle.ncl.edu.tw/11296/z58e2whttps://scholars.csmu.edu.tw/handle/123456789/35077本研究以三十位20歲以上未曾使用降血脂藥物的原發性高膽固醇血症門診病患為對象，(平均年齡53.2±9.8歲)，探討在服用納豆激素四週及八週後血脂改變效果及安全性。結果顯示：服用納豆激素四週後總膽固醇降低6.35%及高密度脂蛋白膽固醇降低6.20%，再經過食用納豆激素八週後總膽固醇降低7.45%，低密度脂蛋白膽固醇降低7.06%及高密度脂蛋白膽固醇降低11.6%，對於肝臟功能、腎臟功能、肌肉組織、血色素及尿酸不影響。本研究顯示納豆激素在高膽固醇血症門診病患可有效降低膽固醇。30 hypercholesterolemia OPD patients who have not taken lipid-lower medications aged above 20 years old (mean 53.2±9.8 years old) comprised the subjects of this study to determine the effects and safety of nattokinase in lipid reduce. The results shown significant reduce total cholesterol in plasma 6.35% and HDL-cholesterol 6.20% in plasma after eating nattokinase for 4 weeks; reduce total cholesterol in plasma 7.45%, LDL-cholesterol 7.06% and HDL-cholesterol 11.6% in plasma after eating nattokinase for 8 weeks. No influence on liver function, renal function, muscle tissue, hemoglobin and uric acid level after eating nattokinase for 8 weeks. This study shown nattokinase reduced total cholesterol in plasma in hypercholesterolemia OPD patients.納豆激素高血脂NattokinaseHyperlipidemiathesis