2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38220This plan mainly is by clinical begins with the foundation two aspects to investigate the relative factor between alcohol addiction and he auditory nerve system impairment including imaginary listens to, sense of hearing suppression and sense of hearing damage and so on. In addition regarding will listen to bond the public figure with must to listen to bury medicated wine of addiction the public figure connection to count and to analyze its proportion by the questionnaire survey way. Discusses from these two aspects discovers its relevance. The implementation concrete way has two sides directions already clinical analysis and the basic research. The clinical aspect collects concerns to the medicated wine addiction patient auditory nerve function examination data (for example Auditory brainstem response, ABR; Distortion-Product Otoacoustic Emissions, OAE and so on), each sole kind becomes addicted to the patient to estimate collects 10 ~ 40 people. Removing of collection mental disease the case is responsible for (cooperation unit) by this school neurology department. Survey the sense of hearing function is responsible by this school ear nose throat Doctor Su Maoch'ang (to cordinate director). The foundation coordination research aspect mainly is (guinea pig) implements the medicated wine addiction and connection the auditory nerve system barrier by the animal pattern, first already only leaves outside the cochlea animal of pattern by the acute alcoholism Mao Hsitsai to give ethyl alcohol of the each kind of different density to discover the appropriate harm density (outside function of the hair cell mobility to appraise whether has reveals injury), chronicity of the animal pattern is poisoned in the blood which (medicated wine addiction pattern) acts according to again appraised the density oral administration appropriate strength of alcohol to simulate it afterwards. Has established animal of the medicated wine addiction pattern except to be possible to make the auditory nerve function examination (for example ABR, OAE and so on) outside, moreover the experimental animal dissection takes out the cochlea and the nervous system, like the hair cell, the cochlea ganglion cell and so on,measurement of mobility , change of and the cell in the its ion electric current the its hair cell the calcium ion change from above these parameters appraised possibly affects the origin and the cell mechanism, obtain with of multiple coefficient of correlation on the clinical chronic alcoholism.此計畫主要是以臨床與基礎兩方面著手探討藥酒癮與聽神經系統障礙之關聯性，包含幻聽、聽覺抑制與聽覺損傷等等。此外對於聽障人士與非聽葬人士之藥酒癮的關聯性將以問卷調查方式統計與分析其比例。從這兩方面去探討以找出其相關性。實施的具體方式有兩個方個方向既臨床分析與基礎研究。 臨床方面收集有關於藥酒癮患者聽神經功能檢測的數據 (如Auditory brainstem response, ABR; Distortion-Product Otoacoustic Emissions, OAE等)，每單一類成癮患者預計收集10 ~ 40人。案例之收集精神疾病之排除由本校精神科負責 (合作單位)。聽覺功能之測量由本校耳鼻喉部蘇茂昌醫師負責 (協同主持人)。 基礎配合研究方面主要是以動物模式 (天竺鼠) 來實施藥酒癮與聽神經系統障礙之關聯性，首先以急性酒精中毒之動物模式既單離耳蝸外毛細再給予各種不同濃度之酒精找出適切之危害濃度 (以外毛細胞運動性之功能評估是否有顯著的傷害)，之後動物模式之慢性中毒 (藥酒癮模式)再根據評估的血中濃度餵食適切的酒精濃度模擬之。已建立藥酒癮模式之動物除可做聽神經功能檢測 (如ABR , OAE等)外，另外實驗動物解剖取出耳蝸和神經系統，如毛細胞，耳蝸神經節細胞等，量測其毛細胞之運動性、其離子電流之變化與細胞內鈣離子的變化從以上這些參數來評估可能影響的來源與細胞機制，以取得與臨床上慢性酒精中毒之相關因子。藥酒癮聽覺障礙聽神經ALCOHOL ABUSEHEARING IMPAIRMENTAUDITORY NERVEProject