2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38803The rate of increase in lung carcinoma mortality in Taiwan is the highest in the world. Approximately 80% of tumors are classified histologically as nonsmall cell lung carcinoma. Numerous studies have shown an association between smoking and lung squamous cell carcinoma (SCC) in both genders. The prevalence of smoking in women is low and lung adenocarcinoma (AC), rather than SCC, is the primary lung cancer cell type among women, it seems possible that risk factors other than smoking exist that may play a more important role in the pathogenesis. Many studies have shown that air pollution could elevate lung cancer. However, data from previous studies on pathological cell types are quite limited. This purpose is to describe the secular trend and geographic variation in histopathology of lung cancer in Taiwan. Two major pathological types (AC and SCC) were considered. We obtain SCC and AC data identified in 1979-2005 through the National Cancer Registration Program operated by the Taiwanese government. Age-adjusted incidence rates of AC and SCC in lung were calculated. Three sets of color maps were made based on “Age-Adjusted Incidence by Rate”, “Age-Adjusted Incidence by Rank” and “Imputed Poisson Trend Surface”. The secular trend and geographic variation in histopathology of lung cancer by sex were shown by using Geographic Information System (GIS).台灣肺癌增加速度較其他國家快速，很多研究顯示吸煙與肺鱗狀細胞癌較有關。台灣地區女性吸煙率不高但肺腺癌卻是女性的主要肺癌發生型態。一般認為除了吸煙外，應該還有更重要的危險因子。究竟是何種原因讓台灣地區的肺癌發生率一直上升?不同的肺癌組織病理型態所隱含的可能是源自不同的暴露因子，又時間趨勢與地理變異的分析在病因學探討中常扮演先驅者角色。因此，本計畫目的即希望透過肺癌組織病理型態的時間趨勢以及地理變異分析，希望能提出造成肺癌發生率上升的可能假說。本研究將完成肺癌及肺癌各組織病理型態別(肺腺癌及肺鱗狀細胞癌為主)之時空趨勢分析。肺癌發生資料(1979-2006)取自全國癌症登記系統。分析方法包括(一)年齡標準化發生率 (二)顯著性P值 (三)補點式卜瓦松趨勢面分析法(IPTS) (四)性別年齡別曲線 (五)長期趨勢圖 (六)國際比較。本研究最後利用地理資訊系統將年齡標準化發生率、顯著性P值及補點式卜瓦松趨勢面分析法(IPTS)的結果繪製成地圖。Project