CHUNG-HAN HSINSHUN-FA YANG2026-10-162026-10-162012-04-01Pure ID: 14928579Pure UUID: 481073a2-23f0-4332-91a6-4a804c71c70f10.1002/hed.21779https://www.scopus.com/pages/publications/84858077257https://scholars.csmu.edu.tw/handle/123456789/26903Background The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer. Results Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073-2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote. Conclusion The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer.6enjournal article