PING-TING LIN2026-10-162026-10-162011-12-01Pure ID: 15391226Pure UUID: fa9ba4e5-b373-4b2b-b201-799d6dd49477https://www.scopus.com/pages/publications/84866633262https://scholars.csmu.edu.tw/handle/123456789/31953Coronary artery disease (CAD) is the leading cause of death in Taiwan. Higher oxidative stress may contribute to the pathogenesis of CAD. Coenzyme Q10 and vitamin E are lipid-soluble vitamins known for their excellent antioxidant qualities. The purpose of this study was to investigate the relationship of coenzyme Q10 and vitamin E concentrations with oxidative stress in patients with CAD. Patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery were assigned to the case group (n = 51). The control group (n = 102) consisted of healthy individuals with normal blood biochemical values. Plasma coenzyme Q10, vitamin E, and malondialdehyde (MDA) concentrations and antioxidant enzyme activities [catalase (CAT) and glutathione peroxidase (GPx)] were measured. Subjects in the case group had significantly lower values of plasma coenzyme Q10, vitamin E, and antioxidant enzyme activities than the control group. Plasma coenzyme Q10 and vitamin E levels were significantly correlated with the MDA level and antioxidant enzyme activities. Patients with CAD were exposed to a higher level of oxidative stress and lower levels of coenzyme Q10 and vitamin E. Further study is needed to examine the benefits of administering coenzyme Q10 or vitamin E to CAD patients, especially those with higher levels of oxidative stress.10enjournal article