CHENG-MING PENG2026-10-162026-10-162014-12-01Pure ID: 15022526Pure UUID: 504eee6f-e26d-4340-a7a3-fd2eb369922c10.4158/EP14181.CRhttps://www.scopus.com/pages/publications/84919954015https://scholars.csmu.edu.tw/handle/123456789/24477Fasting hypoglycemia may occur in subjects with systemic lupus erythematosus (SLE) when accompanied with insulin-binding antibodies or insulin-receptor antibodies. However, insulinoma has not been reported in SLE subjects with hypoglycemia.Methods: We present a case report and review the relevant literature.Results: A 26-year-old female with underlying SLE experienced several episodes of neuropsychiatric symptoms in a fasting state. The steroid dosage was titrated up, but in vain. Timely imaging studies showed a pancreatic tumor, and insulinoma was proven by pathology. Hypoglycemia did not recur after surgery.Conclusion: Physicians should distinguish insulinoma from autoimmunity-mediated hypoglycemia in SLE patients with fasting hypoglycemia.enjournal article