CHIH-LI LIN2026-10-162026-10-162008-01-01Pure ID: 15289520Pure UUID: 5fc2d049-f0c5-4511-a6db-4a8b39faf29bhttps://www.scopus.com/pages/publications/46149100519https://scholars.csmu.edu.tw/handle/123456789/31811Curcumin, a naturally occurring compound derived from turmeric has long been suggested with strong therapeutic or preventive potential to against several major human diseases because of its anti-oxidative, anti-inflammatory, and anti-cancerous effects. Although inflammation is a protective effect, persistent inflammation has been believed to involve in the multistage of cancer development. As a result, the aberrantly increased activity of NF-κB, a master factor playing a key role in inflammation, is implicated in a variety of human cancers. Curcumin is known to exert anti-inflammatory effects significantly by interrupting NF-κB signaling at multiple levels. Many observations indicate that curcumin indeed shows valuable potential in the cancer treatment through inhibiting the activity of 1-κB kinase, IKK. In this review, the anticancer effects of curcumin and the underlying mechanisms are discussed. We also provide a summary of the recent literature focusing on NF-κB signaling pathways and their potential involvement in the development of anticancer strategies.6enjournal article