2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38826Background: Heroin is considered as a “chronic and easy relapse” disorder, and can cause huge impacts on burden of society and economy. Methadone maintenance treatment (MMT) is one of the most efficient methods to deal with heroin dependence. However, one systemic review found the studies regarding influences of MMT on mental health and quality of life were relatively rare. Individuals dropped out with one year of MMT program appeared to reuse the heroin more. Due to high rate of drop-out of MMT, it is essential to distinguish the characteristics of poor outcome and modify the MMT as individual-specific program to improve the treatment outcome of MMT Objectives: The aims of this study are to establish the databank of MMT treatment model in Taiwan through cohort study design, including one-month and one-year outcomes of MMT (including continuous treatment rate, abstinence rate, HIV risk behaviors and quality of life) and predictors of outcome. Methods: The study is a prospective, two centers’ cohort study. The study will be carried out at Chung Shan Medical University Hospital and Tsaotun Psychiatric Center. Eligibility criteria of participants are: (1) heroin use more than one year (2) meet the DSM IV criteria of heroin dependence (3) no treatment of heroin dependence in the preceding month (4) aged equal or more than eighteen (5) no severe physical disorders (6) able to understand and provide written informed consent. The contents of evaluation include characteristics of heroin use and other substances, comorbidity of psychiatric disorders, HIV, Hepatitis B、C and suicide. Participants will be assessed on the entrance, one month, six months and one year of treatment. The indicators of treatment outcomes are retention rate, abstinence rate, HIV risk behaviors and quality of life. The study belongs to second part of two-year cohort study. The present study will follow up 300 participants that have been recruited from MMT program at these two centers (until 2009.7.31) for one year to investigate the treatment outcomes. Expected results: The findings of the present study will demonstrate the different dimensions of outcome and predicting factors for one year outcome of MMT model. The results of this study may be able to demonstrate the important outcomes of MMT in Taiwan, provide the guidance for professionals to modify these factors, provide better treatment model to reduce the relapse of heroin and drop out of MMT, and establish the local model of MMT program.背景：海洛因被認為是一種“慢性而復發＂的疾病，此外海洛因依賴可以造 成巨大的社會及經濟的負擔，美沙冬維持療法（Methadone maintenance treatment, MMT）是治療海洛因成癮的最有效方法之一。然而MMT 對於心理 健康及生活品質的影響的研究仍不多，在第一年的MMT 治療中斷者有較高 的機會復發再用海洛因，如何辨識那些治療不佳者的特徵，在傳統MMT 的 治療模式中根據這些特徵擬定其他的治療計畫，將可增加MMT 的治療效果。 目的：本研究的主要目的為以一世代研究設計，建立以下的本土性MMT 治 療模式資料，包括MMT 治療一個月及一年後的療效（包括持續治療率、是 否繼續使用海洛因、HIV 危險行為及生活品質之改變）及對這些預後的影響 因子。 研究方法：此為一個前驅性(prospective)、兩個治療中心之世代研究(cohort study)。本研究在兩治療中心（中山醫學大學附設醫院及草屯療養院）進行， 研究個案需符合的條件：至少一年以上的海洛因使用、DSM-IV 海洛因依賴 的診斷標準、一個月內未接受海洛因依賴治療者、大於或等於18 歲、無嚴重 生理疾病、可以瞭解研究內容及願意簽署同意書。評估項目為：海洛因及合 併其他物質使用特性、精神疾患的共病性、HIV，B 型肝炎、C 型肝炎及自 殺行為盛行率。評估時間為患者在進入MMT 治療的第一天、第一個月、第 六個月及第十二個月。治療效果指標為第一年後的持續治療（retention）率、 海洛因戒除(abstinence)率、生活品質改善率。預計收集300 名研究個案。收 案時間為一年 (預定98.7 可收集完成)，追蹤這些個案一年以上，總研究時 間共兩年，此計畫為第二年計畫。 預期結果：預期找出進入MMT 治療海洛因依賴患者之生理、心理與社會特 性；找出預測MMT 一年後療效的預測因子，以便能提供臨床醫療人員，及 早針對可能惡化之個案或因素早日介入，達到減少復發的目的，並因此能找 出適合於預防惡化與促進健康的治療模式。Project