CHIN-HUNG LAI2026-10-162026-10-162017-12-01Pure ID: 28724431Pure UUID: 6ccecedf-44e3-48c9-b46a-c776a0dca9b710.1021/acs.joc.7b02240https://www.scopus.com/pages/publications/85036668505https://scholars.csmu.edu.tw/handle/123456789/26571A protecting-group-free synthetic approach to 1-phenylisoquinolin-4-ols was developed by the intramolecular thermal cyclization of methyl 2-[(diphenylmethylidene)amino]acetates. R1 and R2 substituents were found to affect the required reaction temperatures, time, and yields of the cyclized products. The reactivity of the Schiff bases increased upon introduction of α-benzoyl and α-ester groups (R2). The cyclization yield also depended on the position of the R1 substituents on the phenyl groups.8enjournal article