CHUN-WEN CHENGYING-JUI HO2026-10-162026-10-162008-08-06Pure ID: 15063874Pure UUID: 22907ce5-2793-422d-a472-5ff10db55ca210.1097/WNR.0b013e32830b5d86https://www.scopus.com/pages/publications/51649121557https://scholars.csmu.edu.tw/handle/123456789/30379This study aimed to clarify the effects of inescapable and escapable stressors on behavior and interleukin-2 (IL-2) levels in the brain. Inescapable trials, consisting of pairings of conditioned and unconditioned stimuli, were used to induce fear-conditioned stress, whereas trials of escapable pairings of conditioned and unconditioned stimuli in an active avoidance test were used as acute and conditioned stressors. IL-2 levels in the brain were analyzed by enzyme-linked immunoadsorbent assays. Inescapable and escapable stressors had different effects on behavior in the modified active avoidance test and on IL-2 levels in brain areas that are known to be involved in emotional processes. These data provide insight into the pathophysiological role of IL-2 in stress-related disorders.5enjournal article