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  1. Home
  2. Chung Shan Medical University
  3. Project/研究計畫(老師)
  4. 針對微角家塵蟎主要致敏原所誘發的上皮細胞免疫反應之抗細胞黏附藥物篩選
 
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針對微角家塵蟎主要致敏原所誘發的上皮細胞免疫反應之抗細胞黏附藥物篩選

  • Details
Project title
114學年度國家科學及技術委員會補助研究計畫
Acronym
專題研究計畫
Internal ID
NSTC113-2320-B040-012-MY3
Principal Investigator
Liu, Yu-Fan  
Status
research project
Start Date
August 1, 2025
End Date
July 31, 2026
Organizations
Department of Biomedical Sciences  
Partner Organizations
National Science and Technology Council  
Project Web Site
https://www.grb.gov.tw/search/planDetail?id=18137771
Keywords
氣喘
天然化合物
微角家塵蟎
全基因表達分析法
致敏原
功能性食品
Description
家塵蟎為居家環境中誘發氣喘的重要來源之一,氣喘亦是當前環境衛生的重要社會議題。目前缺乏研究人員的長久關注與提出可行的行動綱領,近幾年,微角家塵蟎經由本團隊深入研究,發現台灣中部地區學齡前過敏病童的重要致敏原之一。本團隊利用次世代測序技術,完成微角塵蟎的全基因體分析(WGS),利用體學技術(OMICs) 與專一性抗體開發,完成特定致敏原的檢測鑑定,應用多重轉錄圖譜(RNA-seq) 探究致敏機轉的作用,設置高效篩檢具抗細胞趴附活性的化合物,發展快速自動化篩選的流程、與建立上皮屏障之致敏機制的學理基礎,藉此為廣大長期受到氣喘困擾的病患,提供更精準有效的檢測醫療與功能性食品的開發。
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